San Antonio's 78221 ZIP. Census data shows population of about 41,580, median household income around $63.1k, and 69.8% owner-occupied housing. Tax and business data indicate 21.1% estimated self-employment rate, 17,580 IRS returns in scope, and roughly 533 local businesses in this ZIP. CPA Locator currently tracks 4 CPA firms on CPA Locator and business activity led by Retail trade, Finance and insurance, and Health care and social assistance here.
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